Nerve diseases (NTs) are a group of multi -purpose disorders that are characterized by gradual failure and neurons have disappeared into various parts of the central or surrounding nervous system. NTS, including Alzheimer (AD) Parkinson (BT) and motor neurology (MN), through expansion, cost, basic pathological physics and mechanism based on a device. Scientific studies are related to big problems Common causes of cognitive impairment in the elderly. Diagnosis is difficult, but identifying the main symptoms can help make the correct diagnosis. Early diagnosis and treatment can effectively delay the onset of these diseases. Biomarkers of neurodegenerative diseases are very important for early detection and differential diagnosis Specific and sensitive biomarkers can effectively diagnose disease and monitor disease progression to determine treatment efficacy.